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Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats
Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats
- Source :
- Journal of hypertension. 6(10)
- Publication Year :
- 1988
-
Abstract
- To examine the role of the intrarenal renin-angiotensin system in the development of hypertension in spontaneously hypertensive rats (SHR), we measured angiotensin II contents and tubular 125I-angiotensin II binding sites in the kidney of SHR and age-matched Wistar-Kyoto rats (WKY). In prehypertensive (4-week-old) SHR, not only the kidney angiotensin II content but also the angiotensin II receptor density in brush border membranes were significantly higher than in the WKY. In contrast, angiotensin II levels in the 20-week-old SHR kidneys were significantly lower than in the WKY. Acceleration of the intrarenal renin-angiotensin system and the increased density of tubular angiotensin II receptors in young SHR may therefore play an important role in the development of high blood pressure in SHR.
- Subjects :
- Male
Angiotensin receptor
medicine.medical_specialty
Physiology
Rats, Inbred WKY
Iodine Radioisotopes
Renin-Angiotensin System
Internal medicine
Rats, Inbred SHR
Renin–angiotensin system
Internal Medicine
Medicine
Animals
cardiovascular diseases
Receptor
Kidney
Angiotensin II receptor type 1
Receptors, Angiotensin
biology
business.industry
Angiotensin II
Angiotensin-converting enzyme
Rats, Inbred Strains
Rats
Blood pressure
Endocrinology
medicine.anatomical_structure
Kidney Tubules
Hypertension
cardiovascular system
biology.protein
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 02636352
- Volume :
- 6
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of hypertension
- Accession number :
- edsair.doi.dedup.....039d700df1e71a19d2b026190fb7eb82