Back to Search Start Over

Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats

Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats

Authors :
Minoru Kawamura
Teruo Omae
Keiichi Ito
Yohkazu Matsushima
Morio Kuramochi
Satoshi Akabane
Masahito Imanishi
Source :
Journal of hypertension. 6(10)
Publication Year :
1988

Abstract

To examine the role of the intrarenal renin-angiotensin system in the development of hypertension in spontaneously hypertensive rats (SHR), we measured angiotensin II contents and tubular 125I-angiotensin II binding sites in the kidney of SHR and age-matched Wistar-Kyoto rats (WKY). In prehypertensive (4-week-old) SHR, not only the kidney angiotensin II content but also the angiotensin II receptor density in brush border membranes were significantly higher than in the WKY. In contrast, angiotensin II levels in the 20-week-old SHR kidneys were significantly lower than in the WKY. Acceleration of the intrarenal renin-angiotensin system and the increased density of tubular angiotensin II receptors in young SHR may therefore play an important role in the development of high blood pressure in SHR.

Details

ISSN :
02636352
Volume :
6
Issue :
10
Database :
OpenAIRE
Journal :
Journal of hypertension
Accession number :
edsair.doi.dedup.....039d700df1e71a19d2b026190fb7eb82