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High Oct4 expression: implications in the pathogenesis of neuroblastic tumours
- Source :
- BMC CANCER, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname, Bmc Cancer, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019), BMC Cancer
- Publication Year :
- 2019
- Publisher :
- BIOMED CENTRAL LTD, 2019.
-
Abstract
- Background Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for tumour progression, chemotherapy resistance and recurrence in NBTs. Oct4 is a transcription factor which plays a key role in mammal embryonic development and stem cell fate regulation. The aim of the study is to elucidate the clinical significance of Oct4 in NBTs. Methods We studied Oct4 expression in 563 primary NBTs using digital image quantification. Chi-square test was applied to analyse the correlation between histopathology and the Oct4+ cell percentage. Survival analysis was carried out with Kaplan-Meier curves and log-rank test. Additionally, a multivariate Cox regression analysis with the stepwise backwards (Wald) method was undertaken to calculate the impact of Oct4 expression level on survival. Results We found that tumours with a high proportion of cells expressing Oct4 correlated statistically with undifferentiated and poorly differentiated neuroblastoma / nodular ganglioneuroblastoma, and that Oct4 expression was not present in ganglioneuroma (p
- Subjects :
- Male
0301 basic medicine
Cancer Research
Kaplan-Meier Estimate
Oct4
Biology
lcsh:RC254-282
Neuroblastoma
03 medical and health sciences
0302 clinical medicine
Neuroblastic tumours
Cancer stem cell
Biomarkers, Tumor
Genetics
medicine
Humans
Ganglioneuroma
Survival analysis
reproductive and urinary physiology
Proportional Hazards Models
Ganglioneuroblastoma
Digital image analysis
Gene knockdown
Poorly Differentiated Neuroblastoma
Infant
Neural crest
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Gene Expression Regulation, Neoplastic
030104 developmental biology
Oncology
Neural Crest
030220 oncology & carcinogenesis
embryonic structures
Neoplastic Stem Cells
Cancer research
Female
Octamer Transcription Factor-3
Research Article
Subjects
Details
- ISSN :
- 14712407
- Database :
- OpenAIRE
- Journal :
- BMC CANCER, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname, Bmc Cancer, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019), BMC Cancer
- Accession number :
- edsair.doi.dedup.....0394d358ce6e3b4552b3369a913cdb52