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Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
- Source :
- International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health; Volume 18; Issue 24; Pages: 13253, International Journal of Environmental Research and Public Health, Vol 18, Iss 13253, p 13253 (2021)
- Publication Year :
- 2021
-
Abstract
- Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Methods: We performed a population-based study using the healthcare administrative database of Tuscany. We defined the weekly time series of prevalence and incidence of ASM, along with the incidence of epilepsy-related ED access from 1 January 2018 to 27 December 2020 in the general population. An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. Results: Compared to pre-lockdown, we observed a relevant reduction of ASM incidence (0.65; 95% Confidence Intervals: 0.59–0.72) and ED access (0.72; 0.64–0.82), and a slight decrease of ASM prevalence (0.95; 0.94–0.96). During the post-lockdown the ASM incidence reported higher values compared to pre-lockdown, whereas ASM prevalence and ED access remained lower. Results also indicate a lower impact of the second lockdown for both ASM prevalence (0.97; 0.96–0.98) and incidence (0.89; 0.80–0.99). Conclusion: The lockdowns implemented during the COVID-19 outbreaks significantly affected ASM use and epilepsy-related ED access. The potential consequences of these phenomenon are still unknown, although an increased incidence of epilepsy-related symptoms after the first lockdown has been observed. These findings emphasize the need of ensuring continuous care of epileptic patients in stressful conditions such as the COVID-19 pandemic.
- Subjects :
- Emergency department acce
Epilepsy
SARS-CoV-2
Health, Toxicology and Mutagenesis
Time-series analysi
COVID-19
Italy
epilepsy
anti-seizure medication
emergency department access
time-series analysis
Public Health, Environmental and Occupational Health
Article
Pharmaceutical Preparations
Communicable Disease Control
Medicine
Humans
Emergency Service, Hospital
Pandemics
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health; Volume 18; Issue 24; Pages: 13253, International Journal of Environmental Research and Public Health, Vol 18, Iss 13253, p 13253 (2021)
- Accession number :
- edsair.doi.dedup.....0392c954a10182c13480d741493667f6