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Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alphaâ€
- Source :
- Biology of Reproduction. 100:849-861
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- Systemic inflammation may impair male fertility, and its underlying mechanisms remain poorly understood. The present study investigates the effect of lipopolysaccharide (LPS)-induced systemic inflammation on the testis and epididymis in mice. Intraperitoneal injection of LPS significantly impaired testicular functions, including testosterone production, spermatogenesis, and blood-testis barrier permeability. The epididymitis characterized by leukocyte infiltration and fibrosis was observed in the cauda epididymis after LPS injection. LPS-induced testicular dysfunction and epididymitis were abolished in tumor necrosis factor alpha (Tnfa) knockout mice. Pomalidomide, a TNFA inhibitor, blocked the detrimental effects of LPS on the testis and epididymis. The results indicate that LPS-induced systemic inflammation impairs male fertility through TNFA production, suggesting that the intervention on TNFA production would be considered for the prevention and treatment of inflammatory impairment of male fertility.
- Subjects :
- Lipopolysaccharides
Male
0301 basic medicine
medicine.medical_specialty
Lipopolysaccharide
medicine.medical_treatment
Intraperitoneal injection
Inflammation
Biology
Systemic inflammation
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Fibrosis
Internal medicine
medicine
Animals
Immunologic Factors
Epididymitis
Mice, Knockout
030219 obstetrics & reproductive medicine
Tumor Necrosis Factor-alpha
Cell Biology
General Medicine
medicine.disease
Epididymis
Thalidomide
Chemokine CXCL10
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Gene Expression Regulation
Reproductive Medicine
chemistry
Tumor necrosis factor alpha
medicine.symptom
Subjects
Details
- ISSN :
- 15297268 and 00063363
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Biology of Reproduction
- Accession number :
- edsair.doi.dedup.....038ff7af08d795d285559dfc7be84d20
- Full Text :
- https://doi.org/10.1093/biolre/ioy235