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Vitamin D, PTH and the risk of overall and disease-specific mortality

Authors :: Adriana J. van Ballegooijen
Natasja M. van Schoor
E. Sohl
Marjolein Visser
Paul Lips
Elisa J. de Koning
Jamila El Hilali
Harm W.J. van Marwijk
Internal medicine
Epidemiology and Data Science
EMGO - Musculoskeletal health
General practice
Clinical Neuropsychology
Nutrition and Health
EMGO+ - Lifestyle, Overweight and Diabetes
Source :: El Hilali, J, de Koning, E J, van Ballegooijen, A J, Lips, P, Sohl, E, van Marwijk, H W J, Visser, M & van Schoor, N M 2016, ' Vitamin D, PTH and the risk of overall and disease-specific mortality : Results of the Longitudinal Aging Study Amsterdam ', Journal of Steroid Biochemistry and Molecular Biology, vol. 164, pp. 386-394 . https://doi.org/10.1016/j.jsbmb.2015.12.001, El Hilali, J, de Koning, E J, van Ballegooijen, A J, Lips, P, Sohl, E, van Marwijk, H W J, Visser, M & van Schoor, N M 2016, ' Vitamin D, PTH and the risk of overall and disease-specific mortality: Results of the Longitudinal Aging Study Amsterdam ', Journal of Steroid Biochemistry and Molecular Biology, vol. 164, no. November 2016, pp. 386-394 . https://doi.org/10.1016/j.jsbmb.2015.12.001, Journal of Steroid Biochemistry and Molecular Biology, 164(November 2016), 386-394. Elsevier Limited, Journal of Steroid Biochemistry and Molecular Biology, 164, 386-394. Elsevier Limited
Publication Year :: 2016
Abstract: Observational studies suggest that low concentrations of serum 25-hydroxyvitamin D (25(OH)D) and high concentrations of parathyroid hormone (PTH) are associated with a higher risk of mortality. The aim of this study was to examine whether 25(OH)D and PTH concentrations are independently associated with overall and disease-specific (cardiovascular and cancer-related) mortality in a large, prospective population-based cohort of older adults. Data from 1317 men and women (65-85 years) of the Longitudinal Aging Study Amsterdam were used. Cox proportional hazard analyses were used to examine whether 25(OH)D and PTH at baseline were associated with overall mortality (with a follow-up of 18 years) and disease-specific mortality (with a follow-up of 13 years). Compared to persons in the reference category of ≥75nmol/L, persons with serum 25(OH)D