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Preanalytical Variables Affecting the Integrity of Human Biospecimens in Biobanking
- Source :
- Clinical Chemistry. 61:914-934
- Publication Year :
- 2015
- Publisher :
- Oxford University Press (OUP), 2015.
-
Abstract
- BACKGROUNDMost errors in a clinical chemistry laboratory are due to preanalytical errors. Preanalytical variability of biospecimens can have significant effects on downstream analyses, and controlling such variables is therefore fundamental for the future use of biospecimens in personalized medicine for diagnostic or prognostic purposes.CONTENTThe focus of this review is to examine the preanalytical variables that affect human biospecimen integrity in biobanking, with a special focus on blood, saliva, and urine. Cost efficiency is discussed in relation to these issues.SUMMARYThe quality of a study will depend on the integrity of the biospecimens. Preanalytical preparations should be planned with consideration of the effect on downstream analyses. Currently such preanalytical variables are not routinely documented in the biospecimen research literature. Future studies using biobanked biospecimens should describe in detail the preanalytical handling of biospecimens and analyze and interpret the results with regard to the effects of these variables.
- Subjects :
- Quality Control
Research literature
medicine.medical_specialty
Pathology
Biomedical Research
Future studies
business.industry
Biochemistry (medical)
Clinical Biochemistry
Urine
Biobank
Specimen Handling
Blood
Chemistry, Clinical
medicine
Humans
Personalized medicine
Saliva
business
Intensive care medicine
Biological Specimen Banks
Subjects
Details
- ISSN :
- 15308561 and 00099147
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry
- Accession number :
- edsair.doi.dedup.....0354cd26bdda4a4d4265fd7af6838e60