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SLP-2 is required for stress-induced mitochondrial hyperfusion
- Source :
- EMBO Journal, Vol. 28, No 11 (2009) pp. 1589-600, EMBO Journal, EMBO Journal, EMBO Press, 2009, 28 (11), pp.1589-1600. ⟨10.1038/emboj.2009.89⟩, EMBO J
- Publication Year :
- 2009
-
Abstract
- International audience; Mitochondria are dynamic organelles, the morphology of which results from an equilibrium between two opposing processes, fusion and fission. Mitochondrial fusion relies on dynamin‐related GTPases, the mitofusins (MFN1 and 2) in the outer mitochondrial membrane and OPA1 (optic atrophy 1) in the inner mitochondrial membrane. Apart from a role in the maintenance of mitochondrial DNA, little is known about the physiological role of mitochondrial fusion. Here we report that mitochondria hyperfuse and form a highly interconnected network in cells exposed to selective stresses. This process precedes mitochondrial fission when it is triggered by apoptotic stimuli such as UV irradiation or actinomycin D. Stress‐induced mitochondrial hyperfusion (SIMH) is independent of MFN2, BAX/BAK, and prohibitins, but requires L‐OPA1, MFN1, and the mitochondrial inner membrane protein SLP‐2. In the absence of SLP‐2, L‐OPA1 is lost and SIMH is prevented. SIMH is accompanied by increased mitochondrial ATP production and represents a novel adaptive pro‐survival response against stress.
- Subjects :
- Ultraviolet Rays
Adenosine Triphosphate/metabolism
MFN2
Mitochondria/drug effects/metabolism/physiology/radiation effects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
ddc:616.07
Mitochondrial apoptosis-induced channel
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Mice
0302 clinical medicine
Stress, Physiological
ddc:570
medicine
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Inner mitochondrial membrane
Molecular Biology
Cells, Cultured
030304 developmental biology
0303 health sciences
General Immunology and Microbiology
General Neuroscience
GTP Phosphohydrolases/physiology
Membrane Proteins/physiology
medicine.disease
Mitochondrial carrier
eye diseases
Cell biology
mitochondrial fusion
Dactinomycin/toxicity
Fibroblasts/drug effects/physiology/radiation effects
Translocase of the inner membrane
Optic Atrophy 1
Mitochondrial fission
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 02614189 and 14602075
- Database :
- OpenAIRE
- Journal :
- EMBO Journal, Vol. 28, No 11 (2009) pp. 1589-600, EMBO Journal, EMBO Journal, EMBO Press, 2009, 28 (11), pp.1589-1600. ⟨10.1038/emboj.2009.89⟩, EMBO J
- Accession number :
- edsair.doi.dedup.....03537545079b9a066668b7ff7ec45a41