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Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism
- Source :
- The New England Journal of Medicine, 376, 26, pp. 2534-2544, Stott, D J, Rodondi, N, Kearney, P M, Ford, I, Westendorp, R G J, Mooijaart, S P, Sattar, N, Aubert, C E, Aujesky, D, Bauer, D C, Baumgartner, C, Blum, M R, Browne, J P, Byrne, S L, Collet, T-H, Dekkers, O M, den Elzen, W P J, Du Puy, R S, Ellis, G, Feller, M, Floriani, C, Hendry, K, Hurley, C, Jukema, J W, Kean, S, Kelly, M, Krebs, D, Langhorne, P, McCarthy, G, McCarthy, V, McConnachie, A, McDade, M, Messow, M, O’Flynn, A, O’Riordan, D, Poortvliet, R K E, Quinn, T J, Russell, A, Sinnott, C, Smit, J W A, Van Dorland, H A, Walsh, K A, Walsh, E K, Watt, T, Wilson, R, Gussekloo, J & the TRUST Study Group 2017, ' Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism ', New England Journal of Medicine, vol. 376, no. 26, pp. 2534-2544 . https://doi.org/10.1056/NEJMoa1603825, New England Journal of Medicine, 376(26), 2534-2544, Stott, David J; Rodondi, Nicolas; Kearney, Patricia M; Ford, Ian; Westendorp, Rudi G J; Mooijaart, Simon P; Sattar, Naveed; Aubert, Carole E; Aujesky, Drahomir; Bauer, Douglas C; Baumgartner, Christine; Blum, Manuel R; Browne, John P; Byrne, Stephen; Collet, Tinh-Hai; Dekkers, Olaf M; den Elzen, Wendy P J; Du Puy, Robert S; Ellis, Graham; Feller, Martin; ... (2017). Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. New England journal of medicine NEJM, 376(26), pp. 2534-2544. Massachusetts Medical Society MMS 10.1056/NEJMoa1603825
- Publication Year :
- 2017
-
Abstract
- Item does not contain fulltext BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. METHODS: We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter; free thyroxine level within the reference range). A total of 368 patients were assigned to receive levothyroxine (at a starting dose of 50 mug daily, or 25 mug if the body weight was
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Pediatrics
endocrine system diseases
medicine.medical_treatment
Levothyroxine
Thyrotropin
General Medicine
030209 endocrinology & metabolism
Reference range
610 Medicine & health
030204 cardiovascular system & hematology
Placebo
law.invention
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
Hypothyroidism
law
360 Social problems & social services
Subclinical hypothyroidism
medicine
Humans
Treatment Failure
Fatigue
Subclinical infection
Aged
Aged, 80 and over
Intention-to-treat analysis
business.industry
Thyroid
R1
3. Good health
Intention to Treat Analysis
Clinical trial
Thyroxine
medicine.anatomical_structure
Physical therapy
Quality of Life
Female
Hormone therapy
business
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 00284793
- Database :
- OpenAIRE
- Journal :
- The New England Journal of Medicine, 376, 26, pp. 2534-2544, Stott, D J, Rodondi, N, Kearney, P M, Ford, I, Westendorp, R G J, Mooijaart, S P, Sattar, N, Aubert, C E, Aujesky, D, Bauer, D C, Baumgartner, C, Blum, M R, Browne, J P, Byrne, S L, Collet, T-H, Dekkers, O M, den Elzen, W P J, Du Puy, R S, Ellis, G, Feller, M, Floriani, C, Hendry, K, Hurley, C, Jukema, J W, Kean, S, Kelly, M, Krebs, D, Langhorne, P, McCarthy, G, McCarthy, V, McConnachie, A, McDade, M, Messow, M, O’Flynn, A, O’Riordan, D, Poortvliet, R K E, Quinn, T J, Russell, A, Sinnott, C, Smit, J W A, Van Dorland, H A, Walsh, K A, Walsh, E K, Watt, T, Wilson, R, Gussekloo, J & the TRUST Study Group 2017, ' Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism ', New England Journal of Medicine, vol. 376, no. 26, pp. 2534-2544 . https://doi.org/10.1056/NEJMoa1603825, New England Journal of Medicine, 376(26), 2534-2544, Stott, David J; Rodondi, Nicolas; Kearney, Patricia M; Ford, Ian; Westendorp, Rudi G J; Mooijaart, Simon P; Sattar, Naveed; Aubert, Carole E; Aujesky, Drahomir; Bauer, Douglas C; Baumgartner, Christine; Blum, Manuel R; Browne, John P; Byrne, Stephen; Collet, Tinh-Hai; Dekkers, Olaf M; den Elzen, Wendy P J; Du Puy, Robert S; Ellis, Graham; Feller, Martin; ... (2017). Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. New England journal of medicine NEJM, 376(26), pp. 2534-2544. Massachusetts Medical Society MMS 10.1056/NEJMoa1603825 <http://dx.doi.org/10.1056/NEJMoa1603825>, The New England Journal of Medicine, 376, 2534-2544, New England Journal of Medicine, vol. 376, no. 26, pp. 2534-2544
- Accession number :
- edsair.doi.dedup.....03506b0c89052ddf36b67497c62e2a69