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Kangen-karyu raises surface body temperature through oxidative stress modification
- Source :
- Journal of Clinical Biochemistry and Nutrition
- Publication Year :
- 2016
- Publisher :
- The Society for Free Radical Research Japan, 2016.
-
Abstract
- Kangen-karyu, a prescription containing six herbs, has been shown to achieve its pharmacological effect through oxidative stress-dependent pathways in animal models. The aim of this study is to investigate the relationship between the antioxidative effect and pharmacological mechanisms of Kangen-karyu, specifically its body temperature elevating effect in humans. Healthy human volunteers, age 35 ± 15 years old, were enrolled in this study. Surface body temperature, serum nitrite, reactive oxygen species (ROS) scavenging activities, and inflammatory cytokines were investigated before and 120 min after Kangen-karyu oral intake. Kangen-karyu significantly increased the surface-body temperature of the entire body; this effect was more remarkable in the upper body and continued for more than 120 min. Accompanying this therapeutic effect, serum nitrite levels were increased 120 min after oral administration. Serum ROS scavenging activities were enhanced against singlet oxygen and were concomitantly decreased against the alkoxyl radical. Serum nitrite levels and superoxide scavenging activities were positively correlated, suggesting that Kangen-karyu affects the O2 (•-)-NO balance in vivo. Kangen-karyu had no effect on IL-6, TNF-α and adiponectin levels. These results indicate that the therapeutic effect of Kangen-karyu is achieved through NO- and ROS-dependent mechanisms. Further, this mechanism is not limited to ROS production, but includes ROS-ROS or ROS-NO interactions.
- Subjects :
- 0301 basic medicine
Clinical Biochemistry
Medicine (miscellaneous)
antioxidant capacity
Oxidative phosphorylation
Pharmacology
medicine.disease_cause
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
nitric oxide
Oral administration
medicine
Nitrite
chemistry.chemical_classification
Reactive oxygen species
Nutrition and Dietetics
hydroxyl radical
Adiponectin
Chemistry
Superoxide
alkoxyl radical
030104 developmental biology
Biochemistry
030220 oncology & carcinogenesis
traditional herbal prescription
Original Article
Oxidative stress
Subjects
Details
- ISSN :
- 18805086 and 09120009
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Biochemistry and Nutrition
- Accession number :
- edsair.doi.dedup.....034c4640df57ca91f70060741152d44f