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Human P50 suppression is not affected by variations in wakeful alertness
- Source :
- Biological Psychiatry. 41:891-901
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- The amplitude and suppression of the auditory P50 event-related potential may be useful for studying schizophrenia and drug abuse; however, the low reliability of the P50 suppression measure limits its value for correlation with clinical measures. Reliability can be increased either by improving measurement methods or by reducing or eliminating sources of variance in the recordings. In this paper, the effect on P50 amplitude and suppression of variation in wakeful alertness within an experimental session was examined in 20 normal subjects. The percentage of beta power in the interval immediately prior to the P50 stimuli was used as an index of alertness. P50 amplitudes or C-T ratios were estimated using peak-picking and using the singular value decomposition (SVD) method. No effects of variation of wakeful alertness were observed on any P50 amplitude or suppression measure. Comparing the peak-picking vs SVD estimates replicated our prior results showing markedly higher reliabilities with SVD. We conclude: 1) that variation within an experimental session in wakeful alertness level as indexed by the percentage of beta power does not affect P50 amplitude or suppression, and 2) the SVD method brings the reliability of the C-T ratio up to levels where its usefulness in clinical studies can be examined.
- Subjects :
- Adult
Male
medicine.medical_specialty
Eye Movements
media_common.quotation_subject
Audiology
Electroencephalography
Developmental psychology
Arousal
Correlation
Event-related potential
medicine
Humans
Attention
Wakefulness
Biological Psychiatry
media_common
medicine.diagnostic_test
Electrooculography
Electrophysiology
Alertness
Amplitude
Acoustic Stimulation
Evoked Potentials, Auditory
Female
Beta Rhythm
Psychology
Vigilance (psychology)
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....034a791103da9829798f12aa1f2962aa