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The body region specificity in murine models of muscle regeneration and atrophy
- Source :
- Acta Physiologica (Oxford, England)
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Aim Skeletal muscles are distributed throughout the body, presenting a variety of sizes, shapes and functions. Here, we examined whether muscle regeneration and atrophy occurred homogeneously throughout the body in mouse models. Methods Acute muscle regeneration was induced by a single intramuscular injection of cardiotoxin in adult mice. Chronic muscle regeneration was assessed in mdx mice. Muscle atrophy in different muscles was evaluated by cancer cachexia, ageing and castration mouse models. Results We found that, in the cardiotoxin‐injected acute muscle injury model, head muscles slowly regenerated, while limb muscles exhibited a rapid regeneration and even overgrowth. This overgrowth was also observed in limb muscles alone (but not in head muscles) in mdx mice as chronic injury models. We described the body region–specific decline in the muscle mass in muscle atrophy models: cancer cachexia‐induced, aged and castrated mice. The positional identities, including gene expression profiles and hormone sensitivity, were robustly preserved in the ectopically engrafted satellite cell‐derived muscles in the castrated model. Conclusion Our results indicate that positional identities in muscles should be considered for the development of efficient regenerative therapies for muscle weakness, such as muscular dystrophy and age‐related sarcopenia.
- Subjects :
- muscle atrophy
0301 basic medicine
medicine.medical_specialty
Muscle Physiology
Physiology
030204 cardiovascular system & hematology
Mice
03 medical and health sciences
0302 clinical medicine
Atrophy
Cardiotoxin
Internal medicine
Regular Paper
positional memory
Animals
Regeneration
Medicine
skeletal muscle
Muscular dystrophy
Muscle, Skeletal
business.industry
Muscle weakness
Skeletal muscle
castration
medicine.disease
Muscle atrophy
Mice, Inbred C57BL
Disease Models, Animal
Muscular Atrophy
030104 developmental biology
Endocrinology
medicine.anatomical_structure
ageing
Sarcopenia
Mice, Inbred mdx
Body region
heterogeneity
medicine.symptom
business
cancer cachexia
Subjects
Details
- ISSN :
- 17481716 and 17481708
- Volume :
- 231
- Database :
- OpenAIRE
- Journal :
- Acta Physiologica
- Accession number :
- edsair.doi.dedup.....0348144601310d4192da59886e3adc4b