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The persistence of cone photoreceptors within the dorsal retina of aged retinally degenerate mice (): implications for circadian organization

Authors :
Russell G. Foster
José M. García-Fernández
Antonio J. Jiménez
Source :
Neuroscience Letters. 187:33-36
Publication Year :
1995
Publisher :
Elsevier BV, 1995.

Abstract

Rod- and cone-opsin specific antibodies were used in an attempt to immunolabel remaining photoreceptor cells in the mutant rd (retinal degeneration) mouse retina. We identified a region-specific distribution in the pattern of photoreceptor degeneration, with the dorsal retina showing markedly less photoreceptor degeneration than the ventral retina. All rod and cone immunoreactive cells disappeared in the ventral retina by 100-120 days of age. By contrast, both cone and a small number of rod immunopositive cells were identified in the dorsal retina at this time. By 200 days all rod immunoreactive cells had disappeared. At 360 days numerous cone immunoreactive cells remained within a restricted region of the dorsal retina. As rd mice show unattenuated circadian responses to light, these remaining photoreceptor cells within the dorsal retina become candidates for the regulation of circadian physiology by light.

Details

ISSN :
03043940
Volume :
187
Database :
OpenAIRE
Journal :
Neuroscience Letters
Accession number :
edsair.doi.dedup.....034132cb9da208a0d57f1d9a099be383
Full Text :
https://doi.org/10.1016/0304-3940(95)11330-y