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Development of a tree shrew metabolic syndrome model and use of umbilical cord mesenchymal stem cell transplantation for treatment
- Publication Year :
- 2016
- Publisher :
- Springer Netherlands, 2016.
-
Abstract
- The aim of this study was to establish a tree shrew metabolic syndrome model and demonstrate the utility of MSCs in treating metabolic syndrome. We used tree shrew umbilical cord mesenchymal stem cell (TS-UC-MSC) transplantation for the treatment of metabolic syndrome to demonstrate the clinical application of these stem cells and to provide a theoretical basis and reference methods for this treatment. Tree shrew metabolic syndrome model showed significant insulin resistance, high blood sugar, lipid metabolism disorders, and hypertension, consistent with the diagnostic criteria. TS-UC-MSC transplantation at 16 weeks significantly reduced blood sugar and lipid levels, improved insulin resistance and the regulation of insulin secretion, and reduced the expression levels of the pro-inflammatory cytokines IL-1 and IL-6 (P
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Clinical Biochemistry
Biomedical Engineering
Blood sugar
Bioengineering
Biology
Umbilical cord
03 medical and health sciences
0302 clinical medicine
Insulin resistance
medicine
Liver cell
Mesenchymal stem cell
Cell Biology
medicine.disease
Transplantation
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Immunology
Original Article
Metabolic syndrome
Stem cell
Biotechnology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....03386ed7bd0d212cca122e1b9e02783d