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Brain metastasis in pancreatic cancer
- Source :
- Medicine
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Rationale: Brain metastases are extremely rare for patients with pancreatic adenocarcinoma due to the poor prognoses. In the present study, we reported 2 cases of pancreatic adenocarcinoma with brain metastases. Patient concerns: The 1st patient was diagnosed asymptomatic brain metastasis by a follow-up brain magnetic resonance imaging (MRI) due to a medical history of subarachnoid hemorrhage. The 2nd patient experienced dizziness, neck pain, and seizure. Computed tomography (CT) was used for the diagnosis of brain metastasis because he was inserted a pacemaker. Diagnosis: In case 1, brain MRI revealed that a solitary brain metastasis 14-mm in size was identified at the cortico-medullary junction in the left frontal lobe. In case 2, brain enhanced CT revealed multiple brain metastases with calcification at the cerebral cortex. Times to develop central nervous system metastasis were 19 months and 33 months, respectively. Interventions: The 1st patient was treated with 45.2 Gy γ-knife irradiation for the solitary brain metastasis, and the 2nd patient was treated with supportive care due to the poor general condition. Outcomes: The prognoses of these 2 patients were 13 months, and 32 days from the diagnosis of brain metastasis. The 1st patient did not experience complication of a γ-knife irradiation and brain metastasis was controlled until death. Lessons: The incidence of brain metastases from pancreatic adenocarcinoma is expected to increase due to prolonged survival from improved treatment. Therefore, increased awareness of brain involvement is necessary when neurological disorder is suspected in patients with advanced pancreatic cancer.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Fatal outcome
pancreatic cancer
MEDLINE
Adenocarcinoma
Asymptomatic
03 medical and health sciences
Fatal Outcome
0302 clinical medicine
Text mining
Internal medicine
Pancreatic cancer
medicine
Humans
brain metastasis
Clinical Case Report
030212 general & internal medicine
Aged
treatment
Brain Neoplasms
business.industry
General Medicine
medicine.disease
Pancreatic Neoplasms
030220 oncology & carcinogenesis
Female
prognosis
medicine.symptom
business
Research Article
Brain metastasis
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....0330f66fdd0571b50c82818890203d91