Back to Search
Start Over
Antibacterial activity of ethanolic extract and compounds from fruits of Tectona grandis (Verbenaceae)
- Source :
- BMC Complementary and Alternative Medicine
- Publication Year :
- 2014
-
Abstract
- Background Well known as teak, Tectona grandis is widely used in African folk medicine for its pharmacological relevance. In Cameroon, this species is a reputed laxative in the Northern Region while in the Western Region, it is used in the treatment of skin diseases and diarrhoea. Materials and methods Separation and isolation of compounds were performed using different chromatographic methods while their structures were elucidated by spectroscopic techniques including MS and NMR, and by comparison of data with those reported in the literature. Isolated compounds as well as crude ethanol extract were tested for their antibacterial activities using broth micro-dilution method against four Gram negative bacteria strains Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (PA 01), Klebsiella pneumonia (ATCC 11296) and Escherichia aerogenes (ATCC 13048). Results Three known compounds were isolated, including two quinones and one triterpene. They were identified as tectograndone (1), 6-methyl-1,4-dihydroxyanthraquinone (2), and 2β-hydroxyursolic acid (3) respectively. Crude ethanol extract showed good activity against the bacteria strains tested with MIC of 64–256 μg/mL. Among the isolated metabolites, 6-methyl-1,4-dihydroxyanthraquinone exhibited a strong activity against Escherichia aerogenes with MIC of 16 μg/mL, while tectograndone showed a moderate activity against Escherichia coli with MIC of 32 μg/mL. The antibacterial screening of the fruits of this plant as well as that of compounds 1 and 2 is reported herein for the first time. Conclusion The research work presented here shows that Tectona grandis fruits possess compounds which could be developed in the treatment of bacterial diseases.
- Subjects :
- Terpenoids
medicine.disease_cause
Fruits
Triterpene
Escherichia
Verbenaceae
medicine
Escherichia coli
Tectona grandis
chemistry.chemical_classification
biology
Traditional medicine
Ethanol
Plant Extracts
Quinones
General Medicine
biology.organism_classification
medicine.disease
Anti-Bacterial Agents
Antibacterial
chemistry
Complementary and alternative medicine
Tectona
Fruit
Klebsiella pneumonia
Antibacterial activity
Bacteria
Research Article
Subjects
Details
- ISSN :
- 14726882
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- BMC complementary and alternative medicine
- Accession number :
- edsair.doi.dedup.....032fcb308a7535b13f7b316da507161e