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Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
- Source :
- Future Science OA
- Publication Year :
- 2022
- Publisher :
- Future Science Ltd, 2022.
-
Abstract
- Aim: Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. Materials & methods: We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs). Results: In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs. Conclusion: These findings could be helpful for establishing the molecular carcinogenesis of BTCs.<br />Lay abstract Biliary tract carcinoma, including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic (single nucleotide polymorphism-array) profiling plays important roles in evaluation of the carcinogenesis of biliary tract carcinoma. In the hierarchical cluster analysis, two clusters were identified (subgroup 1 with low somatic copy number alterations [SCNAs] and subgroup 2 with high SCNAs); GBC was found to be predominant in subgroup 1, whereas BDC was predominant in subgroup 2. These findings suggested that GBC and BDC had different genetic backgrounds in terms of SCNAs.
- Subjects :
- Poor prognosis
crypt isolation method
Somatic cell
Duct carcinoma
Single Nucleotide Polymorphism Array
single nucleotide polymorphism array
medicine.disease_cause
bile duct cancer
Bile duct cancer
Medicine
biliary tract carcinoma
business.industry
gall bladder cancer
molecular alteration
medicine.disease
Biliary tract carcinoma
somatic copy number alteration
Cancer research
Gall bladder carcinoma
prognosis
business
Carcinogenesis
carcinogenesis
Research Article
cluster analysis
Biotechnology
Subjects
Details
- ISSN :
- 20565623
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Future Science OA
- Accession number :
- edsair.doi.dedup.....0314b9ab6a4eb44a32fc51aa07346e0c