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Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats
- Source :
- Bioscience, biotechnology, and biochemistry. 65(10)
- Publication Year :
- 2002
-
Abstract
- To discover the role of the kidney in tryptophan degradation, especially tryptophan to niacin, rat kidneys were injured by feeding a diet containing a large amount of adenine. The kidney contains very high activity of aminocarboxymuconate-semialdehyde decarboxylase (ACMSD), which leads tryptophan into the glutaric acid pathway and then the TCA cycle, but not to the niacin pathway. On the other hand, kidneys contain significant activity of quinolinate phosphoribosyltransferase (QPRT), which leads tryptophan into the niacin pathway. The ACMSD activity in kidneys were significantly lower in the adenine group than in the control group, while the QPRT activity was almost the same, however, the formations of niacin and its compounds such as N1-methylnicotinamide and its pyridones did not increase, and therefore, the conversion ratio of tryptophan to niacin was lower in the adenine group than in the control group. The contents of NAD and NADP in liver, kidney, and blood were also lower in the adenine group. The decreased levels of niacin and the related compounds were consistent with the changes in the enzyme activities involved in the tryptophan-niacin metabolism in liver. It was concluded from these results that the conversion of tryptophan to niacin is due to only the liver enzymes and that the role of the kidney would be extremely low.
- Subjects :
- Male
medicine.medical_specialty
Xanthurenates
Aminocarboxymuconate-semialdehyde decarboxylase
3-Hydroxyanthranilic Acid
Biology
Kidney
Kynurenic Acid
Applied Microbiology and Biotechnology
Biochemistry
Niacin
Analytical Chemistry
chemistry.chemical_compound
Internal medicine
medicine
Animals
Renal Insufficiency
Rats, Wistar
Molecular Biology
Nicotinamide
Adenine
digestive, oral, and skin physiology
Organic Chemistry
Tryptophan
nutritional and metabolic diseases
food and beverages
General Medicine
Metabolism
Quinolinic Acid
NAD
Rats
B vitamins
Endocrinology
medicine.anatomical_structure
chemistry
Liver
NAD+ kinase
Biotechnology
Subjects
Details
- ISSN :
- 09168451
- Volume :
- 65
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Accession number :
- edsair.doi.dedup.....031097b49ca922dde5019d7f486176d2