Back to Search
Start Over
Clinical Efficacy of Mitoxantrone and Ara-C with or without Etoposide Salvage Chemotherapy in Adult Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia: Retrospective Multicenter Study of the Korean Adult ALL Working Party
- Source :
- Acta Haematologica. 133:91-97
- Publication Year :
- 2014
- Publisher :
- S. Karger AG, 2014.
-
Abstract
- Mitoxantrone is a conventional agent for relapsed or refractory acute lymphoblastic leukemia (ALL). However, an effective combination with other drugs and a feasible dosage has not been identified. A retrospective study of 46 patients with relapsed or refractory ALL was conducted to determine the efficacy of mitoxantrone and Ara-C treatment with (MEC) and or without etoposide (MC). Twenty-seven and 19 patients received MC and MEC chemotherapy, respectively. Twenty-two (48%) patients showed overall response [complete response (CR), 33%; CR with incomplete platelet recovery (CRp), 15%], and 10 of 22 responders received allogeneic stem cell transplantation (SCT). Median overall survival (OS) was 6.2 months (95% confidence interval, 3.41-9.0). Thirteen (48%) patients in the MC group and 9 (47%) in the MEC group achieved CR/CRp (p = 0.96). Treatment-related mortalities in the MC and MEC groups were 3 (11%) and 4 (21%), respectively (p = 0.36). However, the MEC group frequently presented with grade 3 or higher bacteremia/candidemia (p = 0.013). No difference in OS was observed between the two groups (p = 0.769). In conclusion, salvage therapy consisting of mitoxantrone and Ara-C without etoposide appeared to be an effective bridge therapy to allogeneic SCT for patients with refractory or relapsed ALL.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Salvage therapy
Gastroenterology
Young Adult
Refractory
Recurrence
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Etoposide
Retrospective Studies
Salvage Therapy
Mitoxantrone
Chemotherapy
business.industry
Cytarabine
Retrospective cohort study
Hematology
General Medicine
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Surgery
Transplantation
Treatment Outcome
Bacteremia
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14219662 and 00015792
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Acta Haematologica
- Accession number :
- edsair.doi.dedup.....02ef3c44a64daa920d0b49a235c6c3dc