Back to Search
Start Over
Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues
- Source :
- Molecules, Vol 26, Iss 6548, p 6548 (2021), Molecules, Volume 26, Issue 21
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular matrix can attenuate the invasion of human breast tumor cells. Decreased HA levels in subcutaneous Has3-KO mouse tissues promoted orthotopic breast cancer (E0771) cell-derived allograft tumor growth. MDA-MB-231 cells premixed with higher concentration HA attenuate tumor growth in xenografted nude mice. Human patient-derived xenotransplantation (PDX) experiments found that HA selected the highly migratory breast cancer cells with CD44 expression accumulated in the tumor/stroma junction. In conclusion, HAS3 and HA were detected in the stroma breast tissues at a high level attenuates effects for induced breast cancer cell death, and inhibit the cancer cells invasion at the initial stage. However, the highly migratory cancer cells were resistant to the HA-mediated effects with unknown mechanisms.
- Subjects :
- autophagy
Xenotransplantation
medicine.medical_treatment
Pharmaceutical Science
Organic chemistry
Breast Neoplasms
Article
Analytical Chemistry
Metastasis
chemistry.chemical_compound
Mice
Breast cancer
breast cancer
QD241-441
hyaluronan synthase 3
Drug Discovery
Hyaluronic acid
medicine
Tumor Cells, Cultured
Animals
Humans
tumor microenvironment
RNA, Messenger
Physical and Theoretical Chemistry
Parenchymal Tissue
Mice, Knockout
Tumor microenvironment
biology
CD44
Mammary Neoplasms, Experimental
medicine.disease
Mice, Inbred C57BL
Hyaluronan synthase
chemistry
Chemistry (miscellaneous)
Cancer cell
biology.protein
Cancer research
Molecular Medicine
tubulin acetylation
Female
Hyaluronan Synthases
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 6548
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....02eea2914575aac036b4ffbba23aec6b