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Dominant negative myostatin produces hypertrophy without hyperplasia in muscle
- Source :
- FEBS Letters. (1):71-75
- Publisher :
- Federation of European Biochemical Societies. Published by Elsevier B.V.
-
Abstract
- Myostatin, a TGF-β family member, is a negative regulator of muscle growth. Here, we generated transgenic mice that expressed myostatin mutated at its cleavage site under the control of a muscle specific promoter creating a dominant negative myostatin. These mice exhibited a significant (20–35%) increase in muscle mass that resulted from myofiber hypertrophy and not from myofiber hyperplasia. We also evaluated the role of myostatin in muscle degenerative states, such as muscular dystrophy, and found significant downregulation of myostatin. Thus, further inhibition of myostatin may permit increased muscle growth in muscle degenerative disorders.
- Subjects :
- TGF-β
medicine.medical_specialty
Muscle Fibers, Skeletal
Biophysics
Gene Expression
Mice, Transgenic
Myostatin
Biology
Biochemistry
Muscle hypertrophy
Mice
Downregulation and upregulation
Structural Biology
Transforming Growth Factor beta
Internal medicine
Muscle regeneration
Myokine
Genetics
medicine
Myocyte
Animals
RNA, Messenger
Muscle development
Muscular dystrophy
Muscle, Skeletal
Molecular Biology
Hyperplasia
Cell Biology
Hypertrophy
Muscular Dystrophy, Animal
medicine.disease
Blotting, Northern
musculoskeletal system
Endocrinology
Gene Expression Regulation
Mutagenesis
GDF11
biology.protein
ITGA7
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....02e8ef53bd5ea2a5f40e217b4ccc57d4
- Full Text :
- https://doi.org/10.1016/S0014-5793(00)01570-2