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Clinical, histopathologic and genetic features of rhabdoid meningiomas
- Source :
- International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1116
- Publication Year :
- 2023
- Publisher :
- MDPI, 2023.
-
Abstract
- Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.23 chromosomal region was the most observed chromosomal alteration, followed by losses of chromosomes 14, 1, 6, and 19, polysomies of chromosomes 17, 1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be classified into two genetic subgroups with distinct clinicopathologic features characterized by the presence of (1) chromosomal losses only and (2) combined losses and gains of several chromosomes. The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes. This research was funded by Consejería de Sanidad JCYL, Gerencia Regional de Salud, Spain grant numbers GRS 2132/A/20 and GRS 2315/A/21 and Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain grant number CIBERONC CB16/12/00400.
- Subjects :
- Chromosome copy number alterations
Survival
Organic Chemistry
Histopathology
General Medicine
Rhabdoid meningioma
Prognosis
Catalysis
Computer Science Applications
Inorganic Chemistry
rhabdoid meningioma
chromosome copy number alterations
diagnosis
prognosis
survival
histopathology
Diagnosis
Physical and Theoretical Chemistry
Molecular Biology
Spectroscopy
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1116
- Accession number :
- edsair.doi.dedup.....02dce372cc33e31eba0f77a5815a04af