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GSK-3β activity in the hippocampus is required for memory retrieval
- Source :
- Neurobiology of learning and memory. 98(2)
- Publication Year :
- 2012
-
Abstract
- Several molecules were recently found to be important for the memory retrieval process in the hippocampus; however, the mechanisms underlying the memory retrieval remain poorly understood. GSK-3β has been implicated in the control of synaptic plasticity and memory formation. Here, we investigated the relationship between hippocampal GSK-3β activity and memory retrieval using behavioral and Western blotting methods. We found that GSK-3β was activated in the hippocampus after a retention session in the passive avoidance task. An intrahippocampal injection of the GSK-3β inhibitor, SB 216763, before the retention session blocked memory retrieval (but not reconsolidation) without affecting locomotor activity. These results suggest that GSK-3β activation would be essential for memory retrieval in the hippocampus.
- Subjects :
- Male
Glycogen Synthase Kinase 3 beta
Indoles
Long-term memory
Cognitive Neuroscience
Hippocampus
Retention, Psychology
Experimental and Cognitive Psychology
macromolecular substances
Hippocampal formation
Locomotor activity
Maleimides
Behavioral Neuroscience
Glycogen Synthase Kinase 3
Mice
Synaptic plasticity
Memory formation
Avoidance Learning
Animals
Memory consolidation
Passive avoidance
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 10959564
- Volume :
- 98
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neurobiology of learning and memory
- Accession number :
- edsair.doi.dedup.....02cd864ca18a20dea0c9c80d320f397b