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Enzymatic polymerization of cyclic monomers in ionic liquids as a prospective synthesis method for polyesters used in drug delivery systems
- Source :
- Molecules, Molecules, Vol 20, Iss 1, Pp 1-23 (2014)
- Publication Year :
- 2014
-
Abstract
- Biodegradable or bioresorbable polymers are commonly used in various pharmaceutical fields (e.g., as drug delivery systems, therapeutic systems or macromolecular drug conjugates). Polyesters are an important class of polymers widely utilized in pharmacy due to their biodegradability and biocompatibility features. In recent years, there has been increased interest in enzyme-catalyzed ring-opening polymerization (e-ROP) of cyclic esters as an alternative method of preparation of biodegradable or bioresorbable polymers. Ionic liquids (ILs) have been presented as green solvents in enzymatic ring-opening polymerization. The activity, stability, selectivity of enzymes in ILs and the ability to catalyze polyester synthesis under these conditions are discussed. Overall, the review demonstrates that e-ROP of lactones or lactides could be an effective method for the synthesis of useful biomedical polymers.
- Subjects :
- Biocompatibility
Polyesters
Pharmaceutical Science
Ionic Liquids
Biocompatible Materials
Review
Analytical Chemistry
Polymerization
lcsh:QD241-441
chemistry.chemical_compound
drug delivery systems
lcsh:Organic chemistry
Drug Discovery
Organic chemistry
Physical and Theoretical Chemistry
chemistry.chemical_classification
Drug Carriers
biodegradable polyesters
Organic Chemistry
macromolecular conjugates of drugs
enzymatic ring opening polymerization
Polymer
Biodegradation
Enzymes
Polyester
Monomer
chemistry
Chemistry (miscellaneous)
Cyclization
biomedical polymers
Drug delivery
Ionic liquid
Molecular Medicine
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....02c614c827c0ca19af4a3c0d1e4ab01f