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Evaluating reliability and risk of bias of in vivo animal data for risk assessment of chemicals – Exploring the use of the SciRAP tool in a systematic review context
- Source :
- Environment International, Vol 146, Iss, Pp 106103-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Within the field of health risk assessment, it is essential that evaluations of reliability or validity of toxicity data are conducted with structure and transparency. To this end, different tools for evaluating toxicity studies have been developed by different groups and organizations, for different specific purposes. The Science in Risk Assessment and Policy (SciRAP) tool was developed for use in the regulatory health risk assessment of chemicals and to promote structured and transparent evaluation of study reliability within European regulatory frameworks. As such, the SciRAP tool is not specifically tailored for use in a systematic review context. However, in light of the current movement towards applying systematic review in the field of environmental health and chemical assessments and European chemicals regulation, we were interested in exploring how SciRAP could be applied in such a context. To achieve this, the scope of the SciRAP tool was first compared to two tools developed based on systematic review principles at the US Environmental Protection Agency’s IRIS program and the National Toxicology Program’s Office of Health Assessment and Translation (OHAT). Next, the SciRAP and IRIS tools were both applied in a case study to evaluate the same nine in vivo animal studies and the resulting evaluations were compared. The SciRAP tool was found to address the majority of the elements included for study evaluation in the OHAT and IRIS tools. In the case study, no major differences were found in the conclusions drawn when using SciRAP or IRIS tools. However, future developments to bring the SciRAP tool more in line with systematic review principles were identified and are discussed. Overall, this work illustrates the advantages of applying structured and pre-defined methods for study evaluation and provides a unique case study comparing the impact of using different tools for evaluating animal toxicity studies.
- Subjects :
- 010504 meteorology & atmospheric sciences
Computer science
Context (language use)
010501 environmental sciences
01 natural sciences
Risk Assessment
Animal data
Bias
Agency (sociology)
Animals
Humans
Reliability (statistics)
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
lcsh:GE1-350
OHAT
Health risk assessment
Scope (project management)
Reproducibility of Results
IRIS
SciRAP
Reliability
Risk of bias
ToxRTool
Health assessment
Risk analysis (engineering)
Research Design
Risk assessment
Environmental Health
Systematic Reviews as Topic
Subjects
Details
- Language :
- English
- ISSN :
- 01604120
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- Environment International
- Accession number :
- edsair.doi.dedup.....02c514f361cca995e8e8d9f5871e9c01