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Novel application of quantitative flow ratio for predicting microvascular dysfunction after ST-segment-elevation myocardial infarction
- Source :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventionsREFERENCES. 95
- Publication Year :
- 2019
-
Abstract
- OBJECTIVES This study evaluated quantitative flow ratio (QFR) to predict microvascular dysfunction (MVD) in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND QFR is a novel approach for the rapid computation of fractional flow reserve based on three-dimensional quantitative coronary angiography. We hypothesized that QFR computation could be used to predict MVD after STEMI. METHODS Indexes such as contrast-flow QFR (cQFR), fixed-flow QFR (fQFR), and hyperemic flow velocity (HFV) were calculated in 130 STEMI patients with culprit lesion with ≥50% diameter stenosis and TIMI flow grade 2/3 in the spontaneously recanalized culprit artery on initial angiography. MVD was defined as microvascular obstruction determined by contrast-enhanced cardiac magnetic resonance at a median of 5 days after percutaneous coronary intervention. RESULTS Patients were divided into the MVD group (76/130, 58.5%) and non-MVD group (54/130, 41.5%). Patients with MVD had higher cQFR-fQFR value (0.080 ± 0.058 vs. 0.038 ± 0.039, p
- Subjects :
- Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Fractional flow reserve
030204 cardiovascular system & hematology
Coronary Angiography
Proof of Concept Study
03 medical and health sciences
0302 clinical medicine
Imaging, Three-Dimensional
Percutaneous Coronary Intervention
Predictive Value of Tests
Internal medicine
medicine
ST segment
Humans
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Myocardial infarction
Aged
Retrospective Studies
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Microcirculation
Area under the curve
Percutaneous coronary intervention
Reproducibility of Results
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Fractional Flow Reserve, Myocardial
Treatment Outcome
Angiography
cardiovascular system
Cardiology
Radiographic Image Interpretation, Computer-Assisted
ST Elevation Myocardial Infarction
Female
Cardiology and Cardiovascular Medicine
business
TIMI
Blood Flow Velocity
Subjects
Details
- ISSN :
- 1522726X
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventionsREFERENCES
- Accession number :
- edsair.doi.dedup.....02c04fe06bf02aa6af9d183ac0a4e7ae