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Thioglycine and l-thiovaline: biologically active H2S-donors
- Publication Year :
- 2012
-
Abstract
- Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H(2)S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H(2)S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H(2)S donors hold promise as novel treatments for cardiovascular diseases.
- Subjects :
- Chemistry
Hydrogen sulfide metabolism
Bicarbonate
Organic Chemistry
Clinical Biochemistry
CGMP formation
Pharmaceutical Science
Biological activity
medicine.disease_cause
Biochemistry
chemistry.chemical_compound
Gasotransmitter
Drug Discovery
medicine
Molecular Medicine
Myocyte
Aortic rings
thiovaline, thioglycine
hydrogen sulphide
Molecular Biology
Gasotransmitters
Oxidative stress
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....02c01587f044feaacb1374cd53ed1f7f