Back to Search Start Over

Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico

Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico

Authors :
Paulina Pettinelli
María Fernanda Tumani
Ana María Obregón
Carolina Aguirre
Gladys Tapia
Source :
Revista médica de Chile v.149 n.4 2021, SciELO Chile, CONICYT Chile, instacron:CONICYT
Publication Year :
2021
Publisher :
SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2021.

Abstract

Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes in the composition and function of the IM are associated with different diseases, including NAFLD. In this condition, IM could have a pathogenic role through different mechanisms such as energy salvaging from food, an inflammatory stimulus, a modulation of the innate immune system, regulation of bile acid turnover, alteration of choline metabolism and increasing endogenous ethanol levels. This review is an update on the role of the intestinal microbiota in NAFLD and the possible mechanisms involved.

Details

ISSN :
00349887
Volume :
149
Database :
OpenAIRE
Journal :
Revista médica de Chile
Accession number :
edsair.doi.dedup.....0298d758c5edfce2583444d88bf3d4af
Full Text :
https://doi.org/10.4067/s0034-98872021000400570