Back to Search
Start Over
Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
- Source :
- Revista médica de Chile v.149 n.4 2021, SciELO Chile, CONICYT Chile, instacron:CONICYT
- Publication Year :
- 2021
- Publisher :
- SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2021.
-
Abstract
- Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes in the composition and function of the IM are associated with different diseases, including NAFLD. In this condition, IM could have a pathogenic role through different mechanisms such as energy salvaging from food, an inflammatory stimulus, a modulation of the innate immune system, regulation of bile acid turnover, alteration of choline metabolism and increasing endogenous ethanol levels. This review is an update on the role of the intestinal microbiota in NAFLD and the possible mechanisms involved.
- Subjects :
- Innate immune system
Bile acid
medicine.drug_class
Fatty liver
Endogeny
Non alcoholic
General Medicine
Disease
Biology
medicine.disease
digestive system
digestive system diseases
Gastrointestinal Microbiome
Non-alcoholic Fatty Liver Disease
Hepatocellular carcinoma
Immunology
medicine
Dysbiosis
Function (biology)
Subjects
Details
- ISSN :
- 00349887
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- Revista médica de Chile
- Accession number :
- edsair.doi.dedup.....0298d758c5edfce2583444d88bf3d4af
- Full Text :
- https://doi.org/10.4067/s0034-98872021000400570