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Long-term inhalation of nitric oxide for a patient with primary pulmonary hypertension
- Source :
- Japanese circulation journal. 62(12)
- Publication Year :
- 1999
-
Abstract
- Primary pulmonary hypertension is a disease with a high mortality rate and for which there is no satisfactory medical treatment. The safety of long-term inhalation of nitric oxide (NO) as a treatment is described. A 9-year-old girl inhaled NO for 32 weeks, accompanied with oral administration of beraprost sodium. Although NO did not improve her long-term prognosis, it eased the patient's dyspnea and increased her blood oxygenation. At doses of 20 ppm or more, attempts to withdraw from inhaled NO seemed to lead to an immediate elevation of the pulmonary artery pressure. This rebound phenomenon did not happen at doses under 5 ppm. This case study suggests that long-term inhalation of NO is safe and effective, but that pulmonary hypertension may rebound following withdrawal at higher doses of NO.
- Subjects :
- Time Factors
Physiology
Hypertension, Pulmonary
Vasodilator Agents
Nitric Oxide
Nitric oxide
chemistry.chemical_compound
Oral administration
medicine.artery
Administration, Inhalation
medicine
Humans
Child
Inhalation
business.industry
Respiratory disease
medicine.disease
Pulmonary hypertension
Beraprost
chemistry
Anesthesia
Pulmonary artery
Female
Cardiology and Cardiovascular Medicine
business
Complication
medicine.drug
Subjects
Details
- ISSN :
- 00471828
- Volume :
- 62
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Japanese circulation journal
- Accession number :
- edsair.doi.dedup.....02962ecb9281402abf1c66e23ff47ac1