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Polymyositis as a manifestation of chronic graft-versus-host disease
- Source :
- Medicine. 75(5)
- Publication Year :
- 1996
-
Abstract
- A syndrome indistinguishable from idiopathic polymyositis occurred in 11 patients as a manifestation of chronic GVHD. All patients had elevation of creatine phosphokinase (CPK). Immunohistology demonstrated the effector cells in the muscle infiltrates as cytotoxic T cells, a finding similar to idiopathic polymyositis. Polymyositis is a rarely reported complication of chronic graft-versus-host disease (GVHD) with only 8 cases described in the literature. We encountered this syndrome in a small but significant percentage of our patients with chronic GVHD. Polymyositis associated with chronic GVHD does not affect the overall prognosis for the patient. Moreover, polymyositis can be the only manifestation of chronic GVHD. Awareness of this complication is important because it can be confused with other causes of muscle weakness after bone marrow transplantation. Finally, prompt initiation of corticosteroid therapy results in a rapid improvement of the associated symptoms.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Anti-Inflammatory Agents
Graft vs Host Disease
Disease
Gastroenterology
Polymyositis
Diagnosis, Differential
Internal medicine
Medicine
Cytotoxic T cell
Humans
Child
Bone Marrow Transplantation
Retrospective Studies
biology
business.industry
Muscle weakness
Antibodies, Monoclonal
Infant
General Medicine
Middle Aged
medicine.disease
surgical procedures, operative
Graft-versus-host disease
Child, Preschool
Monoclonal
Chronic Disease
biology.protein
Prednisone
Creatine kinase
Female
medicine.symptom
business
Complication
Subjects
Details
- ISSN :
- 00257974
- Volume :
- 75
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....0291700617d0b0587595c5bd21437bdd