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Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica
- Source :
- International Journal of Nanomedicine
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Mohammed T Al Samri,1,* Rafael Silva,2,* Saeeda Almarzooqi,3 Alia Albawardi,3 Aws Rashad Diab Othman,1 Ruqayya SMS Al Hanjeri,1 Shaikha KM Al Dawaar,1 Saeed Tariq,4 Abdul-Kader Souid,1 Tewodros Asefa2,51Department of Pediatrics, United Arab Emirates University, Abu Dhabi, United Arab Emirates; 2Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; 3Department of Pathology, 4Department of Anatomy, United Arab Emirates University, Abu Dhabi, United Arab Emirates; 5Department of Chemical Engineering and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA*These authors contributed equally to this workAbstract: We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C–SiO2-etched), carbon–silica (C–SiO2), carbon–cobalt–silica (C–Co–SiO2), and carbon–cobalt oxide–silica (C–Co3O4–SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C–SiO2-etched or C–SiO2 nanoparticles. C–SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C–SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C–Co–SiO2 and C–Co3O4–SiO2 impaired lung tissue bioenergetics. C–Co–SiO2, however, increased caspase activity and altered lung structure more than C–Co3O4–SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.Keywords: carbon nanoparticles, cobalt nanoparticles, silica nanoparticles, cobalt oxide nanoparticles, biocompatibility, nanotoxicology
- Subjects :
- Male
Materials science
Biocompatibility
Bioenergetics
Cellular respiration
Biophysics
Pharmaceutical Science
chemistry.chemical_element
Bioengineering
Caspase 3
Nanotechnology
silica nanoparticles
Statistics, Nonparametric
Biomaterials
Mice
biocompatibility
International Journal of Nanomedicine
In vivo
Administration, Inhalation
Materials Testing
Drug Discovery
Animals
Lung
Cobalt oxide
Original Research
cobalt oxide nanoparticles
Respiration
carbon nanoparticles
Organic Chemistry
Cobalt
General Medicine
respiratory system
Silicon Dioxide
Carbon
chemistry
cobalt nanoparticles
Nanotoxicology
Nanoparticles
nanotoxicology
Subjects
Details
- ISSN :
- 11782013
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi.dedup.....026f9bb7ce4fa3601fbf4dfffddb07f4