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Clinicopathological Spectrum of Xanthogranulomatous Pyelonephritis
- Source :
- Indian Journal of Nephrology, Indian Journal of Nephrology, Vol 29, Iss 2, Pp 111-115 (2019)
- Publication Year :
- 2019
- Publisher :
- Medknow Publications & Media Pvt Ltd, 2019.
-
Abstract
- Xanthogranulomatous pyelonephritis (XGP) is an uncommon and distinct type of chronic infective pyelonephritis causing destruction of the kidney, severely affecting the renal function. The perinephric adipose tissue and peritoneum is not uncommonly involved. The study was undertaken to decipher the clinicopathologic spectrum of XGP. Forty cases of XGP were diagnosed on histopathology over a period of 13 years (2005–2017). Relevant clinical details and radiological findings were recorded from the case files. Out of a total of 40 cases, 26 were female and 14 were male with a mean age of 39.5 ± 13.6 years. Flank pain was the most common presenting symptom. All the patients had unilateral disease and underwent nephrectomy for a nonfunctional kidney. Gross examination showed enlarged kidney with replacement of cortico-medullary tissue by yellow nodular areas of fatty tissue and dilatation of the pelvicalyceal system. Thirty-six (90%) cases had nephrolithiasis. Histologically, the characteristic feature was the existence of lipid-laden foamy macrophages. Renal parenchymal involvement was diffuse in majority (31, 77.5%). Two (5.0%) of the patients had coexisting carcinoma in the same kidney. Histopathologic examination gives the definitive diagnosis of XGP which relies on the characteristic morphology. Surgical intervention in the form of nephrectomy is the treatment of choice and offers good treatment outcomes.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
030232 urology & nephrology
Renal function
030230 surgery
lcsh:RC870-923
Nephrectomy
Adipose capsule of kidney
Gross examination
03 medical and health sciences
0302 clinical medicine
medicine
Carcinoma
Kidney
business.industry
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
medicine.anatomical_structure
Nephrology
xanthogranulomatous
pyelonephritis
Histopathology
Original Article
Radiology
Enlarged kidney
business
Subjects
Details
- Language :
- English
- ISSN :
- 19983662 and 09714065
- Volume :
- 29
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....026dd1502b8a82b7823eda3757db2c1b