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A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

Authors :
Bahareh Farasati Far
Mohammad Reza Naimi-Jamal
Maryam Safaei
Kimia Zarei
Marzieh Moradi
Hamed Yazdani Nezhad
Source :
Polymers. 14:5432
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides.

Details

ISSN :
20734360
Volume :
14
Database :
OpenAIRE
Journal :
Polymers
Accession number :
edsair.doi.dedup.....026b7d9c4562d55469a10fee7a198b47
Full Text :
https://doi.org/10.3390/polym14245432