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Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors
- Source :
- Bioorganicmedicinal chemistry letters. 10(15)
- Publication Year :
- 2000
-
Abstract
- A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopropylmethyl (6a, 6g, 6h, and 6k) and N-carboalkoxy (6m-6y) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X.
- Subjects :
- Efavirenz
Clinical Biochemistry
Pharmaceutical Science
Pharmacology
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Quinoxalines
Drug Discovery
Molecular Biology
chemistry.chemical_classification
biology
Chemistry
Organic Chemistry
Nucleotidyltransferase
biology.organism_classification
Reverse transcriptase
HIV Reverse Transcriptase
Enzyme
Enzyme inhibitor
Lentivirus
Lactam
biology.protein
Molecular Medicine
Drug Evaluation
Reverse Transcriptase Inhibitors
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 10
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....026158996c8873b2070f1519aef47b15