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Personalizing Dual-Target Cortical Stimulation with Bayesian Parameter Optimization Successfully Treats Central Post-Stroke Pain: A Case Report

Authors :
Evan M. Dastin-van Rijn
Seth D. König
Danielle Carlson
Vasudha Goel
Andrew Grande
Donald R. Nixdorf
Sarah Benish
Alik S. Widge
Ziad Nahas
Michael C. Park
Tay I. Netoff
Alexander B. Herman
David P. Darrow
Source :
Brain Sciences, Vol 12, Iss 25, p 25 (2022), Brain Sciences
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Central pain disorders, such as central post-stroke pain, remain clinically challenging to treat, despite many decades of pharmacological advances and the evolution of neuromodulation. For treatment refractory cases, previous studies have highlighted some benefits of cortical stimulation. Recent advances in new targets for pain and the optimization of neuromodulation encouraged our group to develop a dual cortical target approach paired with Bayesian optimization to provide a personalized treatment. Here, we present a case report of a woman who developed left-sided facial pain after multiple thalamic strokes. All previous pharmacologic and interventional treatments failed to mitigate the pain, leaving her incapacitated due to pain and medication side effects. She subsequently underwent a single burr hole for placement of motor cortex (M1) and dorsolateral prefrontal cortex (dlPFC) paddles for stimulation with externalization. By using Bayesian optimization to find optimal stimulation parameters and stimulation sites, we were able to reduce pain from an 8.5/10 to a 0/10 during a 5-day inpatient stay, with pain staying at or below a 2/10 one-month post-procedure. We found optimal treatment to be simultaneous stimulation of M1 and dlPFC without any evidence of seizure induction. In addition, we found no worsening in cognitive performance during a working memory task with dlPFC stimulation. This personalized approach using Bayesian optimization may provide a new foundation for treating central pain and other functional disorders through systematic evaluation of stimulation parameters.

Details

Language :
English
ISSN :
20763425
Volume :
12
Issue :
25
Database :
OpenAIRE
Journal :
Brain Sciences
Accession number :
edsair.doi.dedup.....026019fdb13048a029b89b4dd24654ee