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Anti-inflammatory effects of inhaled beclomethasone dipropionate in nonatopic asthmatics
- Source :
- European Respiratory Journal. 9:696-702
- Publication Year :
- 1996
- Publisher :
- European Respiratory Society (ERS), 1996.
-
Abstract
- The effects of inhaled beclomethasone dipropionate (BDP) on asthma symptoms and infiltration of the bronchial mucosa by inflammatory cells were investigated in an open study of 10 patients with mild-to-moderate nonatopic bronchial asthma. Asthma scores were recorded in an asthma diary. Peak expiratory flow (PEF), PEF diurnal variation (PEF%), forced expiratory volume in one second (FEV1%), methacholine airway hypersensitivity (minimum dose of methacholine) (Dmin) were measured. Biopsy of the bronchial mucosa was performed before and after 8 weeks of treatment with BDP (400 micrograms.day-1). The following inflammatory cells were immunostained: eosinophils with anti-EG2; mast cells with AA1; neutrophils with NP57; T-lymphocytes with anti-CD3, CD4, and CD8; and activated T-lymphocytes with anti-CD25. There was a significant improvement in the asthma symptom score, PEF%, FEV1%, and Dmin after BDP therapy and the number of EG2-, AA1-, CD3-, CD4-, and CD25-positive cells decreased significantly. We conclude that inhaled beclomethasone dipropionate inhibited inflammatory cell infiltration of airway tissue and that associated with this there was an improvement of symptoms in this open study of inhaled beclomethasone dipropionate in a group of nonatopic asthmatic subjects.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
Neutrophils
medicine.drug_class
Biopsy
Bronchi
Cell Count
Bronchial Provocation Tests
T-Lymphocyte Subsets
immune system diseases
medicine
Humans
Anti-Asthmatic Agents
Lymphocyte Count
Mast Cells
Asthma
Bronchus
Mucous Membrane
medicine.diagnostic_test
Inhalation
business.industry
Nebulizers and Vaporizers
Respiratory disease
Beclomethasone
Beclometasone dipropionate
Middle Aged
respiratory system
medicine.disease
respiratory tract diseases
Eosinophils
medicine.anatomical_structure
Immunology
Corticosteroid
Female
Methacholine
business
medicine.drug
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....025b3cc59e935316826cce4ca8ac22ea