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Plasma Proteome Database as a resource for proteomics research: 2014 update
- Source :
- Nucleic Acids Research
- Publication Year :
- 2013
- Publisher :
- Oxford University Press (OUP), 2013.
-
Abstract
- Plasma Proteome Database (PPD; http://www.plasmaproteomedatabase.org/) was initially described in the year 2005 as a part of Human Proteome Organization's (HUPO's) pilot initiative on Human Plasma Proteome Project. Since then, improvements in proteomic technologies and increased throughput have led to identification of a large number of novel plasma proteins. To keep up with this increase in data, we have significantly enriched the proteomic information in PPD. This database currently contains information on 10,546 proteins detected in serum/plasma of which 3784 have been reported in two or more studies. The latest version of the database also incorporates mass spectrometry-derived data including experimentally verified proteotypic peptides used for multiple reaction monitoring assays. Other novel features include published plasma/serum concentrations for 1278 proteins along with a separate category of plasma-derived extracellular vesicle proteins. As plasma proteins have become a major thrust in the field of biomarkers, we have enabled a batch-based query designated Plasma Proteome Explorer, which will permit the users in screening a list of proteins or peptides against known plasma proteins to assess novelty of their data set. We believe that PPD will facilitate both clinical and basic research by serving as a comprehensive reference of plasma proteins in humans and accelerate biomarker discovery and translation efforts.
- Subjects :
- Proteomics
Internet
Proteome
Database
Secretory Vesicles
V. Human genome, model organisms, comparative genomics
Blood Proteins
Extracellular vesicle
Serum concentration
Biology
computer.software_genre
Blood proteins
Basic research
Genetics
Human proteome project
Humans
Biomarker discovery
Databases, Protein
computer
Subjects
Details
- ISSN :
- 13624962 and 03051048
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Research
- Accession number :
- edsair.doi.dedup.....024ff7daa68c5e5fb1f9d30aa153f1ed