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Fungal vaccines, mechanism of actions and immunology: A comprehensive review
- Source :
- Biomedicine & Pharmacotherapy, Vol 109, Iss, Pp 333-344 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Fungal infections include a wide range of opportunistic and invasive diseases. Two of four major fatal diseases in patients with human immunodeficiency virus (HIV) infection are related to the fungal infections, cryptococcosis, and pneumocystosis. Disseminated candidiasis and different clinical forms of aspergillosis annually impose expensive medical costs to governments and hospitalized patients and ultimately lead to high mortality rates. Therefore, urgent implementations are necessary to prevent the expansion of these diseases. Designing an effective vaccine is one of the most important approaches in this field. So far, numerous efforts have been carried out in developing an effective vaccine against fungal infections. Some of these challenges engaged in different stages of clinical trials but none of them could be approved by the United States Food and Drug Administration (FDA). Here, in addition to have a comprehensive overview on the data from studied vaccine programs, we will discuss the immunology response against fungal infections. Moreover, it will be attempted to clarify the underlying immune mechanisms of vaccines targeting different fungal infections that are crucial for designing an effective vaccination strategy.
- Subjects :
- 0301 basic medicine
Antifungal Agents
RM1-950
Aspergillosis
Fungal infections
03 medical and health sciences
0302 clinical medicine
medicine
Pneumocystosis
Animals
Humans
Immune response
Pharmacology
Fungal vaccine
Mechanism (biology)
business.industry
General Medicine
medicine.disease
Disseminated Candidiasis
Immunity, Innate
Clinical trial
Vaccination
030104 developmental biology
Mycoses
030220 oncology & carcinogenesis
Cryptococcosis
Immunology
Therapeutics. Pharmacology
Fungal Vaccines
business
Vaccine
Subjects
Details
- ISSN :
- 07533322
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....024bc69a7d245fe922c6fff535ad51b5