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Genome plasticity inNeisseria gonorrhoeae
- Source :
- FEMS Microbiology Letters
- Publication Year :
- 1996
- Publisher :
- Oxford University Press (OUP), 1996.
-
Abstract
- The pathogenic Neisseria have exploited the processes of horizontal DNA transfer and genetic recombination as mechanisms for the generation of extensive protein variation and modulation of gene expression. Localized recombinations have been well documented in members of multigene families as have alterations in short repetitive sequences. Here we report an analysis of the chromosomal structure of a defined lineage of Neisseria gonorrhoeae strain MS 11 pilin variants. This study reveals the occurrence of large rearrangements, including the amplification of a 26 kb region and an inversion involving more than a third of the chromosome. Additionally, a restriction site polymorphism that correlates with pilin expression has been observed. These findings highlight the flexibility of the gonococcal genome.
- Subjects :
- Restriction Mapping
Biology
medicine.disease_cause
Microbiology
Genome
Genetic recombination
Restriction map
Genetics
medicine
Deoxyribonucleases, Type II Site-Specific
Molecular Biology
Gene
Gene Rearrangement
Polymorphism, Genetic
Gene rearrangement
Chromosomes, Bacterial
biology.organism_classification
Neisseria gonorrhoeae
Chromosome Banding
Molecular Weight
Genes, Bacterial
Pilin
biology.protein
Fimbriae Proteins
Neisseria
Bacterial Outer Membrane Proteins
Subjects
Details
- ISSN :
- 15746968 and 03781097
- Volume :
- 145
- Database :
- OpenAIRE
- Journal :
- FEMS Microbiology Letters
- Accession number :
- edsair.doi.dedup.....0249c429200e9bc9ed0cfb9795914b23