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Colocalization of atriopeptin-like immunoreactivity with choline acetyltransferase- and substance P-like immunoreactivity in the pedunculopontine and laterodorsal tegmental nuclei in the rat
- Source :
- Brain research. 382(1)
- Publication Year :
- 1986
-
Abstract
- Atriopeptin, the atrial natriuretic peptide, is a circulating hormone that plays an important role in the regulation of fluid and electrolyte balance. Immunohistochemical studies have shown that large, multipolar atriopeptin-like immunoreactive (APir) neurons are present in areas of the midbrain corresponding to the large neurons of the pedunculopontine tegmental (PPT) and lateral dorsal tegmental (TLD) nuclei, all of which can be stained immunohistochemically for choline acetyltransferase-like immunoreactivity (ChATir). A subpopulation of these cholinergic PPT and TLD neurons are also known to contain substance P-like immunoreactivity (SPir). Using an immunofluorescent technique that allows simultaneous localization of two antigens, we have studied the relationship between APir, SPir and ChATir in the pontine tegmentum of the rat. We have found that (i) the large multipolar APir neurons of the pontine tegmentum are identical to the ChATir neurons of the PT and TLD nuclei and (ii) a subpopulation of the APir neurons in PPT and TLD neurons are also SPir.
- Subjects :
- Male
medicine.medical_specialty
Interpeduncular nucleus
Tegmentum Mesencephali
Fluorescent Antibody Technique
Substance P
Biology
Choline O-Acetyltransferase
Midbrain
chemistry.chemical_compound
Internal medicine
Pons
medicine
Tegmentum
Animals
Molecular Biology
Neurons
General Neuroscience
Colocalization
Brain
Rats, Inbred Strains
Choline acetyltransferase
Rats
Endocrinology
nervous system
chemistry
Cholinergic
Neurology (clinical)
Atrial Natriuretic Factor
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 382
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Brain research
- Accession number :
- edsair.doi.dedup.....0248cc75078df016f4ab7ad0552862e8