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Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct : A Mendelian Randomization Study
- Source :
- Vissers, L E T, Sluijs, I, van der Schouw, Y T, Forouhi, N G, Imamura, F, Burgess, S, Barricarte, A, Boeing, H, Bonet, C, Chirlaque, M-D, Fagherazzi, G, Franks, P W, Freisling, H, Gunter, M J, Quirós, J R, Ibsen, D B, Kaaks, R, Key, T, Khaw, K T, Kühn, T, Mokoroa, O, Nilsson, P M, Overvad, K, Pala, V, Palli, D, Panico, S, Sacerdote, C, Spijkerman, A M W, Tjonneland, A, Tumino, R, Rodríguez-Barranco, M, Rolandsson, O, Riboli, E, Sharp, S J, Langenberg, C & Wareham, N J 2019, ' Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct : A Mendelian Randomization Study ', Diabetes Care, vol. 42, no. 4, pp. 568-575 . https://doi.org/10.2337/dc18-2034, Diabetes Care, Diabetes Care, 42(4), 568. American Diabetes Association Inc.
- Publication Year :
- 2019
-
Abstract
- OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. RESULTS Each additional LP allele was associated with a higher intake of milk (β 17.1 g/day, 95% CI 10.6–23.6) and milk beverages (β 2.8 g/day, 95% CI 1.0–4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (β −7.0 g/day, 95% CI −12.4 to −1.7 per additional LP allele), nonalcoholic beverages (β −18.0 g/day, 95% CI −34.4 to −1.6), and wine (β −4.8 g/day, 95% CI −9.1 to −0.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratioper 15 g/day 0.99, 95% CI 0.93–1.05). CONCLUSIONS rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.
- Subjects :
- Male
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
LACTASE PERSISTENCE
Cohort Studies
Eating
0302 clinical medicine
Endocrinology
Risk Factors
Neoplasms
Medicine
030212 general & internal medicine
Advanced and Specialised Nursing
Lactase
Incidence
Mendelian Randomization Analysis
11 Medical And Health Sciences
Middle Aged
PROSTATE-CANCER
Diabetes and Metabolism
Milk
NUTRITION
Female
HEALTH
Cohort study
Adult
Genotype
GENETIC VARIANT
QUESTIONNAIRE
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Article
Endocrinology & Metabolism
03 medical and health sciences
Diabetes mellitus
Environmental health
Mendelian randomization
Internal Medicine
Journal Article
Animals
Humans
Product (category theory)
VALIDITY
Advanced and Specialized Nursing
business.industry
Case-control study
CONSUMPTION
medicine.disease
Nutrition Assessment
Diabetes Mellitus, Type 2
Case-Control Studies
Gene-Environment Interaction
Dairy Products
business
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Database :
- OpenAIRE
- Journal :
- Vissers, L E T, Sluijs, I, van der Schouw, Y T, Forouhi, N G, Imamura, F, Burgess, S, Barricarte, A, Boeing, H, Bonet, C, Chirlaque, M-D, Fagherazzi, G, Franks, P W, Freisling, H, Gunter, M J, Quirós, J R, Ibsen, D B, Kaaks, R, Key, T, Khaw, K T, Kühn, T, Mokoroa, O, Nilsson, P M, Overvad, K, Pala, V, Palli, D, Panico, S, Sacerdote, C, Spijkerman, A M W, Tjonneland, A, Tumino, R, Rodríguez-Barranco, M, Rolandsson, O, Riboli, E, Sharp, S J, Langenberg, C & Wareham, N J 2019, ' Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct : A Mendelian Randomization Study ', Diabetes Care, vol. 42, no. 4, pp. 568-575 . https://doi.org/10.2337/dc18-2034, Diabetes Care, Diabetes Care, 42(4), 568. American Diabetes Association Inc.
- Accession number :
- edsair.doi.dedup.....024715e8e1489813d233c1eae3bb0076