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Adaptation of the Blood Antioxidant Defence Mechanisms of Sheep with a Genetic Lesion Resulting in Low Red Cell Glutathione Concentrations
- Source :
- Free Radical Research Communications. 18:177-181
- Publication Year :
- 1993
- Publisher :
- Informa UK Limited, 1993.
-
Abstract
- Finnish Landrace sheep with a genetic lesion which results in restricted cysteine transport across the red cell membrane have total glutathione concentrations in their red blood cells that are approximately 40% of those in normal sheep of the same breed. However, dimethyldisulphide-challenged red blood cells from both phenotypes produce an ESR-spin adduct at similar rates. The resistance of the low glutathione phenotype red cells to oxidant challenge is reflected by increases in the activities of antioxidant enzymes. Sheep with a genotypic disorder in cysteine transport may be a suitable model for studying the genetic expression of antioxidant enzymes in response to oxidant loads.
- Subjects :
- Erythrocytes
Antioxidant
Free Radicals
medicine.medical_treatment
Cysteine transport
Biology
Biochemistry
Antioxidants
Lesion
Lipid peroxidation
chemistry.chemical_compound
medicine
Animals
Sheep
Glutathione Disulfide
Red Cell
Electron Spin Resonance Spectroscopy
Glutathione
Adaptation, Physiological
Enzyme Activation
Red blood cell
Phenotype
medicine.anatomical_structure
chemistry
Glutathione disulfide
Female
medicine.symptom
Subjects
Details
- ISSN :
- 87550199
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Free Radical Research Communications
- Accession number :
- edsair.doi.dedup.....0241b21945bb1dec89e46c108dade8a8