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Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice

Authors :
Fred F. Kadlubar
Peter P. Fu
L. S. Von Tungeln
Kenneth L. Dooley
Ronald W. Hart
Thomas J. Bucci
Source :
Carcinogenesis. 15(2)
Publication Year :
1994

Abstract

Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.

Details

ISSN :
01433334
Volume :
15
Issue :
2
Database :
OpenAIRE
Journal :
Carcinogenesis
Accession number :
edsair.doi.dedup.....023c540e15d4c0f902e516cf927da25c