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Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice
- Source :
- Carcinogenesis. 15(2)
- Publication Year :
- 1994
-
Abstract
- Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.
- Subjects :
- Adenoma
Male
Cancer Research
medicine.medical_specialty
Liver tumor
DNA damage
Ratón
DNA repair
Biology
medicine.disease_cause
Chrysenes
Mice
Liver Neoplasms, Experimental
Internal medicine
medicine
Bioassay
Animals
Carcinogen
Biotransformation
Caloric theory
General Medicine
medicine.disease
Endocrinology
Carcinogens
Carcinogenesis
Energy Intake
Food Deprivation
DNA Damage
Subjects
Details
- ISSN :
- 01433334
- Volume :
- 15
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Carcinogenesis
- Accession number :
- edsair.doi.dedup.....023c540e15d4c0f902e516cf927da25c