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INTRAMUSCULAR FAT AND INFLAMMATION DIFFER IN OLDER ADULTS: THE IMPACT OF FRAILTY AND INACTIVITY
- Publication Year :
- 2014
-
Abstract
- OBJECTIVES: Intramuscular adipose tissue (IMAT) is recognized as a negative predictor of both muscle and mobility function in older adults, however the mechanism by which IMAT may negatively influence muscle and mobility function is currently unknown. The release of pro-inflammatory cytokines from IMAT provides a potential reason for these negative associations. To explore this hypothesis we compared IMAT and muscular inflammation in age-and BMI-matched older non-obese frail and non-frail adults. We also sought to examine the relationship between IMAT and inflammation, and muscle and mobility function in this group of older adults. DESIGN: A case-control sampling was used for this study. Age-and BMI-matched non-obese frail and non-frail individuals (
- Subjects :
- Oncology
Male
medicine.medical_specialty
Aging
Frail Elderly
Medicine (miscellaneous)
Adipose tissue
Inflammation
Walking
Article
Body Mass Index
Internal medicine
Isometric Contraction
medicine
Humans
Frail elderly
Obesity
RNA, Messenger
Muscle, Skeletal
Gait
Quality of Life Research
Aged
Aged, 80 and over
Nutrition and Dietetics
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Case-control study
Magnetic Resonance Imaging
Adipose Tissue
Thigh
Case-Control Studies
Physical therapy
Female
Intramuscular fat
Geriatrics and Gerontology
medicine.symptom
Sedentary Behavior
business
Body mass index
human activities
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....023baf36e6ced897d32607a6ba3896d3