Back to Search
Start Over
Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth
- Source :
- BioFactors. 6:359-366
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- Ras, a signal-transducing protein involved in mediating growth factor-stimulated proliferation, is mutationally activated in over 30% of human tumors. To be functional Ras must bind to the inner surface of the plasma membrane, with post-translational lipid modifications being necessary for this localization. The essential, first modification of Ras is farnesylation catalyzed by the enzyme farnesyl: proteintransferase (FPTase). Inhibitors of FPTase (FTIs) are currently being tested to determine if they are capable of tumor growth inhibition. Here we describe our efforts, along with those of other groups, in testing the biological and biochemical effects of FTIs.
- Subjects :
- Clinical Biochemistry
Protein Prenylation
Antineoplastic Agents
Biology
Biochemistry
Prenylation
Transferases
Neoplasms
Tumor Cells, Cultured
Animals
Humans
Tumor growth
Enzyme Inhibitors
chemistry.chemical_classification
Alkyl and Aryl Transferases
General Medicine
Cell biology
Genes, ras
Membrane
Enzyme
chemistry
ras Proteins
Molecular Medicine
Tumor growth inhibition
lipids (amino acids, peptides, and proteins)
Subjects
Details
- ISSN :
- 18728081 and 09516433
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- BioFactors
- Accession number :
- edsair.doi.dedup.....023693b2591ad29d03e4f7323078444e