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Ovarian cancer in Lynch syndrome; a systematic review
- Source :
- European Journal of Cancer. 55:65-73
- Publication Year :
- 2016
-
Abstract
- Objective: The aim was to systematically review the characteristics of ovarian cancer in women with Lynch syndrome (LS) and evaluate the role of surveillance in detection of ovarian cancer in LS. Methods: All studies between 1979 and 2015 of women with ovarian cancer and LS or at 50% risk of LS were evaluated. Two reviewers independently evaluated eligible studies and extracted data on age at diagnosis, histological type, FIGO stage, and way of detection according to pre-specified criteria. The studies were assessed for quality using the Newcastle-Ottawa quality assessment scales. Results: The quality score of the 49 identified studies was at least 6 out of 8 and provide clinical information on 747 LS women with ovarian cancer. The mean age at diagnosis was 45.3 (range 19-82) years. Most frequent mutations were MSH2 (47%) and MLH1 (38%). Histopathological data were available for 445 women. The most frequently reported histological type was mixed type (mucinous/endometrioid/clear cell carcinomas) (n = 136; 31%). Most tumours (281, 65%) were diagnosed at an early stage (FIGO I/II). Six studies evaluating the effect of surveillance of ovarian cancer, reported that seven of 22 (32%) ovarian cancers were found during surveillance, 6/7 (86%) were detected at an early stage. Conclusion: This systematic review describes that ovarian cancer in women with LS has a wide age-range of onset, is often diagnosed at an early stage with frequently endometrioid/clear cell histology. Data about the role of surveillance in detection of ovarian cancer in women with LS are scarce however detection at an early stage seems possible. (C) 2015 Elsevier Ltd. All rights reserved.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
Time Factors
endocrine system diseases
MICROSATELLITE INSTABILITY
Gene mutation
0302 clinical medicine
Risk Factors
GYNECOLOGIC CANCERS
Medicine
Stage (cooking)
Young adult
Age of Onset
EXTRACOLONIC CANCERS
Early Detection of Cancer
Aged, 80 and over
Ovarian Neoplasms
Surveillance
MSH2 MUTATION
NONPOLYPOSIS COLORECTAL-CANCER
Middle Aged
RANDOMIZED CONTROLLED-TRIAL
Prognosis
Lynch syndrome
female genital diseases and pregnancy complications
Pedigree
Phenotype
030220 oncology & carcinogenesis
Predictive value of tests
BRCA1/2 MUTATION CARRIERS
Screening
Female
Carcinoma, Endometrioid
GENE-MUTATIONS
Adult
medicine.medical_specialty
03 medical and health sciences
Young Adult
Predictive Value of Tests
Ovarian cancer
Internal medicine
Biomarkers, Tumor
Humans
Genetic Predisposition to Disease
Aged
Neoplasm Staging
Gynecology
business.industry
Endometrial cancer
ENDOMETRIAL CANCER
medicine.disease
Colorectal Neoplasms, Hereditary Nonpolyposis
030104 developmental biology
Mutation
Systematic review
Age of onset
business
REPAIR PROTEIN DEFECTS
Subjects
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.doi.dedup.....02237d6ba100fb6f83d22bea6615ef02