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The Prognostic Value of High-Sensitive Troponin I in Stable Coronary Artery Disease Depends on Age and Other Clinical Variables
- Source :
- Cardiology. 132(1)
- Publication Year :
- 2014
-
Abstract
- Objectives: To study the prognostic value of high-sensitive troponin (hs-cTn) I in stable coronary artery disease. Methods: In total, we studied 705 patients. Secondary outcomes were the incidence of: (1) acute ischemic events and (2) heart failure or death. The primary outcome was the composite of them. Results: Patients with hs-cTnI >0 ng/ml (62.1%) were older, had a lower estimated glomerular filtration rate, more frequent a history of hypertension, atrial fibrillation, ejection fraction 0 was associated with a higher risk of developing the primary outcome [relative risk = 2.360 (1.359-4.099); p = 0.001] and heart failure or death [relative risk = 5.932 (1.806-19.482); p < 0.001], but not with acute ischemic events. Statistical significance was lost after controlling for age. By logistic regression analysis, age [relative risk = 1.026 (1.009-1.044); p = 0.003], ejection fraction 0. Conclusions: In stable coronary disease, hs-cTnI is associated with the incidence of heart failure or death, but this relationship depends on other variables.
- Subjects :
- Male
medicine.medical_specialty
Clinical variables
Renal function
Angiotensin-Converting Enzyme Inhibitors
Coronary Artery Disease
Kaplan-Meier Estimate
Coronary artery disease
Risk Factors
Internal medicine
medicine
Humans
Pharmacology (medical)
Aged
Proportional Hazards Models
Heart Failure
biology
Proportional hazards model
business.industry
Troponin I
Anticoagulants
Middle Aged
medicine.disease
Prognosis
Troponin
Logistic Models
High sensitivity troponin
biology.protein
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Value (mathematics)
Biomarkers
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 14219751
- Volume :
- 132
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cardiology
- Accession number :
- edsair.doi.dedup.....02134266d73a43883a917a23dc54905a