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N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor
- Source :
- Journal of Medicinal Chemistry, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2014
-
Abstract
- On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
- Subjects :
- Models, Molecular
Cell Membrane Permeability
Indoles
Monoamine Oxidase Inhibitors
Cell membrane permeability
Swine
Stereochemistry
Monoamine oxidase
Multipotent models
Drug design
03 medical and health sciences
Synthesis
0302 clinical medicine
Piperidines
Drug Discovery
Animals
Cholinesterases
QD
Monoamine Oxidase
030304 developmental biology
Biological evaluation
Cholinesterase
Indole test
0303 health sciences
Molecular Structure
biology
Chemistry
QSAR
Dual inhibitor
Brain
QD Chemistry
3. Good health
Blood-Brain Barrier
biology.protein
Molecular Medicine
Amine gas treating
Cholinesterase Inhibitors
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....020b7a4eb644740851530536d54500fb