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Clinicopathologic factors associated with recurrence and long-term survival in node-negative advanced gastric cancer patients
- Source :
- Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 111(2)
- Publication Year :
- 2018
-
Abstract
- Background: despite a better prognosis in node-negative advanced gastric cancer (GC), a proportion of patients have a tumor recurrence within five years and eventually die due to cancer-related causes. The present study aimed to evaluate the predictive factors of tumor recurrence and long-term survival in node-negative advanced GC. Methods: a total of 646 node-negative advanced GC patients who underwent a curative gastrectomy in our institution were included in the study. The impact of different clinicopathologic factors on tumor recurrence and overall survival were analyzed. Results: tumor recurrences were observed in 181 patients and the cumulative recurrence rate at two-years and five-years were 50.8% and 86.2%, respectively. Lymphovascular invasion, advanced T stage (T3-T4) and an inadequate number of retrieved lymph nodes (LNs) were independent predictive factors of tumor recurrence in node-negative advanced GC. Older age, an upper 1/3 tumor, lymphovascular invasion, infiltration growth pattern (INFγ) and the depth of tumor invasion (T4 stage) were independently associated with long-term survival. With regard to node-negative patients with ≥ 15 retrieved LNs, infiltration growth pattern (INFγ) and advanced T stage (T3-T4) were independent risk factors for both tumor recurrence and long-term survival. Conclusion: in addition to lymphovascular invasion, inadequate RLNs and advanced T stage, the prognostic significance of infiltration growth pattern in node-negative advanced GC was especially emphasized. These risk factors should be considered when selecting candidates for adjuvant chemotherapy and postoperative surveillance.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Time Factors
Adjuvant chemotherapy
Lymphovascular invasion
medicine.medical_treatment
Adenocarcinoma
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Cancer Survivors
Gastrectomy
Risk Factors
Stomach Neoplasms
Internal medicine
Long term survival
medicine
Overall survival
Humans
Neoplasm Invasiveness
Aged
Aged, 80 and over
Analysis of Variance
business.industry
Carcinoma
Gastroenterology
Age Factors
General Medicine
Advanced gastric cancer
Middle Aged
Node negative
030220 oncology & carcinogenesis
Lymphatic Metastasis
T-stage
Lymph Node Excision
030211 gastroenterology & hepatology
Female
Lymph Nodes
Neoplasm Recurrence, Local
business
Erythrocyte Transfusion
Subjects
Details
- ISSN :
- 11300108
- Volume :
- 111
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
- Accession number :
- edsair.doi.dedup.....01fd47d1d51cd9c2ba67e39560d5ca12