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CD58 Immunobiology at a Glance
- Source :
- Frontiers in Immunology, Vol 12 (2021), Frontiers in Immunology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand CD2 is primarily expressed on the surface of T/NK cells. The CD2-CD58 interaction is an important component of the immunological synapse (IS) that induces activation and proliferation of T/NK cells and triggers a series of intracellular signaling in T/NK cells and target cells, respectively, in addition to promoting cell adhesion and recognition. Furthermore, a soluble form of CD58 (sCD58) is also present in cellular supernatant in vitro and in local tissues in vivo. The sCD58 is involved in T/NK cell-mediated immune responses as an immunosuppressive factor by affecting CD2-CD58 interaction. Altered accumulation of sCD58 may lead to immunosuppression of T/NK cells in the tumor microenvironment, allowing sCD58 as a novel immunotherapeutic target. Recently, the crucial roles of costimulatory molecule CD58 in immunomodulation seem to be reattracting the interests of investigators. In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a comprehensive summary of CD58 immunobiology.
- Subjects :
- Graft Rejection
0301 basic medicine
Immunological Synapses
Lymphoma
T-Lymphocytes
CD58
Immunology
CD2 Antigens
Review
Autoimmune Diseases
Immunological synapse
Immunomodulation
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
Antigens, Neoplasm
Neoplasms
Cell Adhesion
Tumor Microenvironment
Humans
Protein Isoforms
Immunology and Allergy
Intestinal Mucosa
Cell adhesion
Receptor
immune evasion
Tumor microenvironment
Leukemia
T cell activation
Chemistry
lymphocyte functional antigen-3
Endothelial Cells
RC581-607
CD58 Antigens
CD2
Cell biology
Killer Cells, Natural
Transplantation
030104 developmental biology
Gene Expression Regulation
030220 oncology & carcinogenesis
Cytomegalovirus Infections
Cytokines
Tumor Escape
LFA-3
Immunologic diseases. Allergy
Signal Transduction
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....01f1b85dd57b5c9ec6253536089a8629