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The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies
- Source :
- Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 17(7)
- Publication Year :
- 2020
-
Abstract
- The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.
- Subjects :
- Blood Glucose
endocrine system
Sleeve gastrectomy
medicine.medical_specialty
medicine.medical_treatment
Gastric Bypass
Bariatric Surgery
030209 endocrinology & metabolism
Type 2 diabetes
Carbohydrate metabolism
Glucagon-Like Peptide-1 Receptor
03 medical and health sciences
0302 clinical medicine
Gastrectomy
Glucagon-Like Peptide 1
Medicine
Humans
Insulin
Receptor
Glucagon-like peptide 1 receptor
Glycemic
business.industry
digestive, oral, and skin physiology
nutritional and metabolic diseases
medicine.disease
Glucagon-like peptide-1
Surgery
Postprandial
Diabetes Mellitus, Type 2
030211 gastroenterology & hepatology
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 18787533
- Volume :
- 17
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
- Accession number :
- edsair.doi.dedup.....01ee2ac65988d3dbb76cd9273e043035